Scheme 6.
Synthesis of the linker derivative 23. Reagents and conditions: a) 1. DSC, anhydrous K2CO3, dry CH3CN, 0 °C, 20 h; 2. propargylamine, KHCO3, 0 °C →rt, 5 h. Boc=tert-butoxycarbonyl, DSC=N,N′-hydroxysuccinimidyl carbonate.
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