Table 2.
MicroRNAs involved in skin diseases
| miRNAs | Levels | Gene Targets | Effect | References |
|---|---|---|---|---|
| Skin cancer | ||||
| miR-221/222 | Up | P27Kip1 | Increased cell proliferation | 49 |
| miR-221/222 | Up | cKit | Increased melanogenesis | 49 |
| miR-137 | Up | MITF | Dysregulated melanocyte development, survival, function | 8 |
| miR-182 | Up | MITF, FOXO3 | Increased metastasis | 124 |
| miR-21 | Up | PTEN, TPM1, PDCD4, RECK, TIMP3 | Increased metastasis | 24, 52, 53, 102, 169, 170 |
| miR-17-5p, miR-18a, miR-106b, miR-93 | Up | E2F, CDKN1, BIM | Increased cell proliferation, reduced apoptosis | |
| miR-196a | Down | HOXB7 | Increased migration | |
| miR-193b | Down | CCND1 | Increased cell proliferation | |
| miR-200b, miR-200c, miR-141, miR-205 | Down | E-cadherin | Increased invasion and metastasis | 138 |
| let-7a, let-7b | Down | ras, cyclin, CDK4 | Increased tumor progression | 24, 68, 113, 123 |
| Psoriasis | ||||
| miR-146a | Up | IRAK1/TRAF6 | 133, 137 | |
| miR-125b | Down | TNF-α | Constant activation of STAT3 and subsequent development of psoriatic plaques | 132, 141 |
| miR-203, miR-21 | Up | Not well defined | 15, 23 | |
| Systemic sclerosis | ||||
| miR-29a | Up | Type I and type III collagens | Increased collagen deposition and fibrosis | 98 |