Table 3.
MicroRNAs involved in different phases of wound healing
| MicroRNAs | Targets | References |
|---|---|---|
| Inflammatory phase | ||
| miR-105 | TLR2 | 9 |
| miR-140 | PDGF receptor | 42 |
| miR-146a, miR-125b | TNF-α | 132 |
| Angiogenesis | ||
| Proangiogenic miRNAs | ||
| miR-17-92 | TSP-1, CTGF | 38, 135 |
| miR-126 | Spred1, PIK3R2 | 51, 80, 150 |
| miR-130a | GAX, HOXA5 | 25 |
| miR-210 | EFNA3 | 46, 115 |
| miR-296 | HGS | 154 |
| miR-378 | Fus-1, Sufu | 85 |
| Antiangiogenic miRNAs | ||
| miR-92a | Integrin-α5 | 13 |
| miR-17 | Janus Kinase 1 | 39 |
| miR-15b,miR-16, miR-20a, miR-20b | VEGF | 61 |
| miR-320 | IGF-1 | 152 |
| miR-221, miR-222 | c-kit | 112 |
| Proliferative phase | ||
| miR-184 | Akt | 51, 150, 166 |
| miR-205 | SHIP2, Rho-ROCK1 | 166 |
| miR-210 | E2F3, ISCU 1/2 | 11 |
| Remodeling phase | ||
| miR-29a | Type I and type II collagen | 98 |
| miR-29b,29c | Smads, β-catenin | 91, 148 |
| miR-192 | SIP1 | 72 |