Table 1.
Temporal changes in the microRNA transcriptome following ischemic stroke
| miRNA | Early Phase ≤24 h | Late Phase 24–72 h | Authors | |
|---|---|---|---|---|
| Upregulated at one or both phases | 17 | up (J) | up (D) | D, J |
| 134 | up | up | D, J | |
| 140 | up | up | D, J | |
| 145 | up | up | D, J | |
| 206 | up | up | D, J | |
| 214 | up | up | D, J | |
| 290 | up | up | D, J | |
| 320 | up | up | D, J | |
| 330 | up | up | D, J | |
| 331 | up | up | D, J | |
| 292-5p | up (J) | up (D) | D, J | |
| 324-3p | up | up | D, J | |
| 324-5p | up | up | D, J | |
| 422b | up (J) | up (D) | D, J | |
| 223 | NC | up | D, J, L | |
| Mixed at both phases | 7a | down (J) | down (D), up (J) | D, J |
| 20a | down (J) | up (D) | D, J | |
| 25 | down (J) | up (D) | D, J | |
| 138 | up (J) | down (D) | D, J | |
| 151 | down (J) | up (D) | D, J | |
| 361 | down (J) | up (D) | D, J | |
| Downregulated at one or both phases | 26b | down | down | D, J |
| 27a | down (J) | down (D, J) | D, J | |
| 29b | down | down | D, J | |
| 29c | down | down | D, J | |
| 30e | down | down | D, J | |
| 98 | down | down | D, J | |
| 137 | down (J) | down (D, J) | D, J | |
| 218 | down (J) | down (D, J) | D, J | |
| 335 | down (J) | down (D, J) | D, J | |
| 664 | down (D, J) | down (D) | D, J | |
| 379 | NC | down | D, J | |
| 539 | NC | down | D, J |
Table collates microRNA common to at least 2 of 3 preclinical studies to perform transcriptome-wide analysis following focal cerebral ischemia in rat. Final column designates studies in agreement: D(12), J(28), L(39). NC, no change. Note: specific conditions of experimental MCAO differ across studies and likely contribute to variability in transcriptome changes. For example, D and J employed transient ischemia while L employed permanent ischemia. Refer to original manuscripts for detailed descriptions of experimental stroke procedures.