Table 2.

Differentiation of low and high grade dysplasia and gastric carcinomas

Histology	Feature	Low-grade dysplasia	High-grade dysplsia	Carcinoma
Structural atypia	Gland size	Uniform	Variable	Variable
	Gland arrangement	Regular	Slightly irregular	Irregular
	Glandular crowding	Slight	Moderate	Marked
	Glandular transition to surrounding mucosa	No	No	No
	Glandular branching/budding	Focal	Prominent	Prominent
	Glandular cribriform	No	Yes	Yes
	Surface maturation	No	No	No
Nuclear atypia	Shape	Elongated	Elongated and/or irregular	Oval/round
	Pseudostratification	Basal 1/2	Over basal 1/2	Irregular
	Membrane	Thin	Thick	Uneven
	Hyperchromasia	Hyperchromatic even	Hyperchromatic irregular	Vesicular
	Pleomorphism	No	Mild	Moderate to marked
	Prominent nucleoli	Absent	Present	Present
	Loss of polarity	No	No/yes	Yes
Stroma	Invasion	No	No	Yes