Table 2.

Testing mirBridge on several known phenotypes compiled from the literature. The q values were computed based on simultaneous testing across miRNA seeds for the gene set. Black: significant; blue: marginally significant; gray: not significant. See also Table S2.

miRNA	Known function	p	q	rank (out of 143 seed-matched motifs)	References
141/200a	epithelial-mesenchymal transition	0.0018	0.08	1	(Burk et al., 2008; Gregory et al., 2008b; Korpal et al., 2008b; Park et al., 2008)
21	apoptosis	0.006	0.39	1	(Chan et al., 2005)
155	B cell receptor signaling	0.007	0.29	5	(Thai et al., 2007)
181	T cell receptor signaling	0.008	0.07	5	(Li et al., 2007)
34	P53 pathway	0.04	0.32	14	(Chang et al., 2007; He et al., 2007; Raver-Shapira et al., 2007; Tarasov et al., 2007)
223	granulocyte differentiation	0.07	0.62	15	(Johnnidis et al., 2008)
let-7	non-small cell lung cancer	0.55	0.63	68	(Esquela-Kerscher et al., 2008; Johnson et al., 2007; Kumar et al., 2008)
122	cholesterol biosynthesis	0.83	0.99	103	(Krutzfeldt et al., 2005)
133	cardiac hypertrophy	0.94	0.86	134	(Care et al., 2007)