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Impaired IL6 production in Pml −/− MEFs. Secreted IL6 was measured in the medium by ELISA and is expressed relative to total protein content of incubated MEFs. Five independent experiments showed a statistically significant 2-fold decrease of IL6 protein secretion from Pml −/− versus wild-type MEFs after LPS treatment. The mean values are presented by the solid lines ± standard deviation.
