Table 1.

Human Trials of Hypertonic Saline Prior to 2000

Reference	Population	Design	N	Hypertonic Fluid	Outcome
Holcroft et al., 1987	Prehospital trauma patients	Prospective, randomized	49	7.5%NaCL/6%Dextran70	Improved SBP and overall survival
Holcroft et al., 1989	Hypotensive trauma pts in ED (SBP < 80)	Prospective, randomized	32	7.5%NaCL/6%Dextran70	No difference in survival
Vassar et al., 1991	Prehospital trauma patients (SBP < 100)	Prospective, randomized	166	7.5%NaCL/6%Dextran70	Improved SBP& improved survival for pts with TBI
Mattox et al., 1991	Prehospital trauma patients (SBP < 90) 72% penetrating inj	Prospective, randomized	359	7.5%NaCL/6%Dextran70	Improved SBP, Trend toward improved survival, decrease in ARDS
Younes et al., 1992	Hypovolemic shock in ED (SBP < 80)	Prospective, randomized	105	7.5% NaCl & 7.5%NaCL/6%Dextran70	Improved SBP, no difference in survival
Vassar et al., 1993	Prehospital trauma patients (SBP< 90)	Prospective, randomized	258	7.5% NaCl & 7.5%NaCL/6%Dextran70	Improved survival vs. predicted MTOS
Vassar et al., 1993	Prehospital trauma patients (SBP< 90)	Prospective, randomized	194	7.5% NaCl & 7.5%NaCL/6%Dextran70	Improved survival vs. MTOS & for pts with TBI
Younes et al., 1997	Hypovolemic shock in ED	Prospective, randomized	212	7.5%NaCL/6%Dextran70	Improved survival for pts with SBP < 70