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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: J Immunol. 2011 May 18;186(12):6990–6998. doi: 10.4049/jimmunol.1100396

Fig. 7. Human macrophages from CF patients are hyper-responsive to LPS.

Fig. 7

(A) Mean ± standard deviation of TLR4 expression in macrophages from healthy donors and patients with CF; isotype control is also shown; (B) p-ERK1/2 assessed in untreated (0) and LPS treated (5, 20 and 60 minutes) HD and CF macrophages by western blot normalized to b-actin, data are from 3 separate experiments with different CF and HD samples; a representative blot is shown (right); (C) mean ± SEM cytokine concentration in the supernatant of HD (open triangle) and CF patient (close circles) macrophages untreated (0) and treated with LPS as indicated. Statistical analysis was performed by two-sample t-tests.