Table 1.
Summary of genes (proteins) and their protein-protein interactions in four organisms
| Organism | No. of interactions | No. of proteins | Proportion of genome (%)a | No. of genes (proteins)b |
|||
|---|---|---|---|---|---|---|---|
| Cancer genes | Non-cancer disease genes | Essential genes | Control genes | ||||
| Human | 50,100 | 10,324 | 43.70 | 370 (420) | 3132c (4666) | 1832c (2253) | 5857 (5857) |
| Fly | 25,026 | 7474 | 54.06 | 94 (123) | 834 (1205) | 596 (796) | 1412 (1908) |
| Worm | 6876 | 3885 | 19.25 | 34 (74) | 331 (911) | 249 (584) | 574 (1469) |
| Yeast | 54,376 | 5433 | 92.37 | 35 (35) | 355 (362) | 213 (217) | 652 (669) |
a
Proportion of the proteins in the interactome over the total number of proteins encoded by the protein-coding genes in the genome.
b
Number of genes whose proteins could be found in the protein-protein interaction network. The numbers in parentheses are all the available genes categorized by the corresponding annotations in each organism (i.e., some genes whose proteins could not be found in the PPI dataset).
c
Specifically in the human genome, there are 867 genes overlapped between non-cancer disease genes and essential genes.