Table 2.
Network topology properties of four sets of proteins in four organisms
| Organism | Cancer proteins | Non-cancer disease proteins | Essential proteins | Control proteinsa |
|---|---|---|---|---|
| Degree | ||||
| Human | 24.48 (0)b | 10.70 (0) | 16.17 (0) | 7.14 (1) |
| Fly | 12.36 (0) | 7.26 (0.023) | 8.54 (0) | 7.24 |
| Worm | 8.50 (0) | 4.82 (0) | 5.30 (0) | 4.23 |
| Yeast | 38.29 (0.017) | 28.13 (0.001) | 32.80 (0.001) | 31.08 |
| Distance | ||||
| Human | 3.60 (0) | 3.94 (0.836) | 3.77 (0) | 3.98 (1) |
| Fly | 4.13 (0.011) | 4.24 (0.023) | 4.20 (0.001) | 4.24 |
| Worm | 4.30 (0.010) | 4.60 (0.446) | 4.49 (0.005) | 4.58 |
| Yeast | 2.77 (0.003) | 2.83 (0) | 2.80 (0) | 2.82 |
| Betweenness centrality | ||||
| Human | 5.34×104 (0) | 1.79×104 (0) | 2.95×104 (0) | 0.84×104 (1) |
| Fly | 3.08×104 (0) | 1.40×104 (0.023) | 1.74×104 (0) | 1.32×104 |
| Worm | 2.01×104 (0.007) | 1.04×104 (0) | 1.06×104 (0.001) | 0.83×104 |
| Yeast | 0.72×104 (0.102) | 0.70×104 (0.105) | 0.82×104 (0.090) | 0.85×104 |
a
The P-values of control proteins in fly, worm and yeast were not included because proteins homologous to human control proteins did not account for a large proportion of the proteins in the interactome of the three organisms.
b
The P-values based on randomization analysis are included in parentheses.