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. Author manuscript; available in PMC: 2012 Apr 29.
Published in final edited form as: Cell. 2011 Apr 29;145(3):341–355. doi: 10.1016/j.cell.2011.04.005

Figure 3. Signaling pathways activated in the lesional macrophage.

Figure 3

Various pro- and anti-inflammatory forces act on the macrophage in atherosclerotic lesions leading to activation of downstream cascades, such as the inflammasome, scavenger receptor (SR)/Toll-like receptor (TLR) cooperative signaling, ER stress, expression of the sterol responsive network, and efflux of cholesterol via ABCA1 and ABCG1 transporters.