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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Mar 17;31(6):1300–1308. doi: 10.1161/ATVBAHA.111.223701

Figure 4. Enhanced Neointima Formation in PTEN iKO mice is Dependent on SDF-1α.

Figure 4

(A) qPCR analysis for SDF-1α mRNA in injured femoral arteries from WT and PTEN iKO mice. β-Actin was used for normalization of cDNA. (B) Serum from 7-d and 3-w post-injured WT and PTEN iKO mice was analyzed by ELISA for SDF-1α levels. (C) (Top) Timeline of experimental protocol. H&E staining on 3-w injured femoral arteries from WT and PTEN iKO mice treated with control or SDF-1α neutralizing antibodies. Intima-to-media ratios (left) and percent stenotic areas (right) were calculated and are presented in the graphs. *Different from WT; **PTEN iKO + αSDF-1α different from PTEN iKO + control IgG; n=6.