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. Author manuscript; available in PMC: 2011 Jun 9.
Published in final edited form as: Nat Immunol. 2010 Mar 28;11(5):385–393. doi: 10.1038/ni.1859

Figure 6.

Figure 6

The AIM2 inflammasome is critical for innate immunity against Francisella infection. (a), Survival of Aim2+/+ and Aim2−/− mice injected subcutaneously with F. novicida (1.5 × 105 CFU) (Aim2+/+ n = 9, Aim2−/− n=9), and monitored over a period of 3 weeks. 66% of Aim2+/+ survived beyond 3 weeks post-infection. (b), Livers and spleens were harvested 48 h post-infection of mice subcutaneously with F. novicida (1.0 × 105 CFU) homogenized, and dilutions plated on Cystine Heart Agar plates for enumeration of CFU. Bacterial counts from the livers and spleens of the Aim2−/− were significantly higher compared with Aim2+/+ mice (P 0.0054, and 0.0011, respectively). (c) Enzyme-linked immunosorbent assay of IL-18 in serum from Aim2+/+ mice (n = 3) and Aim2−/− mice (n = 3) at 1 d after subcutaneous infection with F. novicida. In b,c, each symbol represents an individual mouse; small horizontal lines indicate the mean. P values, Kaplan-Meier log-rank test (a) or Student’s t-test (b,c). Data are representative of two experiments.