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Effect of Smad4 haploinsufficiency (S4+/−) on aortic signaling. Western blot analysis of the proximal ascending aorta in three mice each: WT, S4+/−, Fbn1C1039G/+, and S4+/−:Fbn1C1039G/+. Note the unique activation of JNK1 in S4+/−:Fbn1C1039G/+ mice compared with all other genotypes. Values are means ± 2 SEM. *P < 0.05; **P < 0.01; NS, not significant.
