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. Author manuscript; available in PMC: 2011 Jun 9.
Published in final edited form as: Neuropharmacology. 2008 Jun 27;56(1):22–29. doi: 10.1016/j.neuropharm.2008.06.037

Table 1.

Survival of mice lacking multiple TARPs

Colony Breeding scheme Age(1) +/+ +/− −/− Litters Chi square
γ-2,3 γ-2+/−;γ-3−/− P0 59 111 41 37 P = 0.16
X γ-2+/−;γ-3−/− (28%) (53%) (19%)
P14 62 106 7 46 P < 0.0001
(35%) (61%) (4%)
Died 5 23 27 30 P < 0.0001
<P14 (9%) (42%) (49%)
γ-2,4 γ-2+/−;γ-4−/− (2) 13 32 11 23 P = 0.52
X γ-2+/−;γ-4−/− (23%) (57%) (20%)
γ-2,8 γ-2+/−;γ-8−/− (3)
X γ-2+/−;γ-8+/−
γ-2,3,4 γ-2+−;γ -3−/−;γ -4−/− E18.5 15 36 5 10 P < 0.05
X γ-2+/−;γ -3−/−;γ -4−/− (27%) (64%) (9%)
γ-2,3,8 γ-2+/−;γ-3−/−;γ-8−/− (4)
X γ-2+/−;γ-3−/−;γ-8+/−
γ-3,4 γ-3−/−;γ-4−/− (2) — — (100%) (5)
X γ-3−/−;γ-4−/−
γ-3,4,8 γ-3−/−;γ-4−/−;γ-8+/− (2) 38 74 25 17 P = 0.27
X γ-3−/−;γ-4−/−;γ-8+/− (28%) (54%) (18%)
(1)

Genotypes of offspring are tabulated by postnatal (P) or embryonic (E) age in days.

(2)

Age did not influence the proportions of offspring in these crossings, in which no early deaths were observed.

(3)

In our limited experience with this breeding, we did successfully produce γ-2,8 KO offspring, some of whom died soon after birth and some who lived long enough for acute slice experiments (Rouach et al., 2005).

(4)

In our limited attempts to breed these mice, no living γ-2,3,8 KO pups resulted (12.5% predicted); of the dead pups genotyped, approximately half were γ-2,3,8 KOs.

(5)

These homozygous breeding pairs produced normal litters of healthy offspring. During creation of this line, γ-3,4 KO mice and their heterozygous siblings appeared in normal Mendelian ratios (P = 0.34)