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. Author manuscript; available in PMC: 2011 Jun 9.
Published in final edited form as: Neuron. 2010 Jun 10;66(5):739–754. doi: 10.1016/j.neuron.2010.04.029

Figure 1. Aβ Oligomers Bind to Excitatory Synapses.

Figure 1

(A) Labeling of Homer1b/c (red) and gephyrin (blue) in neurons incubated for 5 min with b-Aβo (500 nM). b-Aβo were labeled with streptavidin (green). Bar: 2 μm.

(B) Quantification of colocalization between b-Aβo and Homer or gephyrin normalized to the relative proportion of each kind of synapse (mean ± SEM; t test, ***p < 0.0001; n = 13 neurites).

(C) Detail of the square indicated in (A) showing in separate channels the immunoreactivity of Homer (arrows) and Gephyrin (triangles) and the labeling of b-Aβo (top panels). Bottom panels show merge images of b-Aβo and Homer (left) or Gephyrin (right) and the triple merging (center). Bar: 1 μm.