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. 2011 May 3;104(11):1680–1685. doi: 10.1038/bjc.2011.144

Table 6. Cox regression results – relative hazards for screen-detected vs symptomatic tumours, the effect of adjustment for prognostic factors and correction for lead time, and the Freedman (199 percentage of the survival advantage of screen-detected tumours accounted for by adjustment and correction).

Correction for lead time Adjustment Relative hazard (95% CI) Freedman percentage
No None 0.34 (0.31–0.36)
  Size and node status 0.56 (0.50–0.61) 46
  NPI 0.70 (0.63–0.78) 67
Yes None 0.48 (0.45–0.52) 32
  Size and node status 0.90 (0.82–0.99) 90
  NPI 1.20 (1.09–1.33) 100

Abbreviations: CI=confidence interval; NPI=Nottingham Prognostic Index.