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. 2011 May 10;104(11):1716–1723. doi: 10.1038/bjc.2011.146

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Copyright © 2011 Cancer Research UK

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Schematic representation of the chimeric ImmunoRNase, Erb-hcAb-RNase, obtained by fusing the human compact antibody Erb-hcAb and the HP-RNase. Erbicin=the human anti-ErbB2 scFv; H=hinge; CH2-CH3=the heavy constant domains of the human IgG1 Fc; S=the spacer peptide AAASGGPEGGS linking the scFv-Fc and the RNase moieties; HP-RNase=the RNase moiety.