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. 2011 May 24;104(11):1770–1778. doi: 10.1038/bjc.2011.82

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Copyright © 2011 Cancer Research UK

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Box and Whisker plot and Kaplan–Meier disease-free survival analysis for CRC patients according to miR-148a hypermethylation pattern. (A) The 10-year survival rate (60%) of CRC patients was calculated using the Kaplan–Meier method. (B) Survival rate of CRC patients according to depth of invasion. The difference is statistically significant (log-rank test: P<0.05). (C) The prognostic value of miR-148a methylation status was with a trend towards lower survival rate in patients with methylated alleles (10-year survival probability: 48%) compared with unmethylated cases (10-year survival probability: 65%), log-rank test: P=0.561.