Table 2. miRNAs upregulation after the treatment with AZA.
hsa-miR | HCT116 | HT29 | Expression in CRC | Functions | References | |
---|---|---|---|---|---|---|
1 | 15b | 1.43 | 2.29 | ↑ | Cell cycle | Xi et al (2006) |
2 | 96 | 1.58 | 2.3 | ↑ | DNA repairs | Bandrés et al (2006); Sarver et al (2009) |
3 | 99a | 3.85 | 2.23 | ↑ | Cell inhibition | Chen et al (2008) |
4 | 106a | 1.23 | 2.15 | ↓↑ | NA | Díaz et al (2008); Link et al (2010) |
5 | 129 | 2.6 | 2.56 | ↓ | Cell death | Bandres et al (2009); Huang et al (2009) |
6 | 135b | 1.75 | 2.02 | ↑ | DNA repairs | Wang et al (2010) |
7 | 146 | 1.09 | 2.63 | ↓↑ | Anti metastatic | Hurst et al (2009); Slattery et al (2011) |
8 | 148a | 1.05 | 3.96 | ↓ | Methylation | Lujambio et al (2008); Chen et al (2010) |
9 | 181c | 3.62 | 1.94 | ↓ | Oncogenic suppresion | Hashimoto et al (2010) |
10 | 219 | 1.31 | 3.41 | ↑ | NA | Schetter et al (2008) |
11 | 338 | 1.85 | 2.47 | NA | NA | NA |
12 | 34b/c | 2.8 | 3.1 | ↓ | Cell cycle and apoptosis | Toyota et al (2008) |
Abbreviations: AZA=5-aza-2′-deoxycytidine; CRC=colorectal cancer; miRNAs=microRNAs; NA=data not available.