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. 2011 May 24;9(5):906–921. doi: 10.3390/md9050906

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 2. — Acetylation of arylalkylamines by wild type and mutant AANATs. Activities were measured in the presence of near saturating levels of AcCoA and increasing concentration of amine substrates. The graphs represent acetylation activities (mean ± SE) with serotonin and phenylethylamine. A generally similar kinetics was found with tryptamine and dopamine. The AANAT1a- α2, β4 and αa mutants did not express well and were inactive, consistent with misfolding, and therefore were not analyzed (see ‘Experimental Section’ for details). (A) AANAT1a and mutants with serotonin; (B) AANAT1a and mutants with phenylethylamine; (C) AANAT2 and mutants with serotonin; (D) AANAT2 and mutants with phenylethylamine; PEA = phenylethylamine.