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| Adverse event | Grade 3 | Grade 4 |
|---|---|---|
| Neutropaenia | 1 | 0 |
| Lymphopaenia | 22 | 0 |
| Thrombocytopaenia | 1 | 0 |
| Anaemia | 2 | 1 |
| Fatigue | 11 | 0 |
| Neurological | 6 | 0 |
| Lethargy | 3 | 0 |
| Diarrhoea | 3 | 0 |
| Dyspnoea | 1 | 0 |
| Vomiting | 1 | 1 |
| Malaise | 1 | 0 |
| Indigestion | 1 | 0 |
| Ischaemic attack | 1 | 0 |
