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. 2011 May 17;104(12):1913–1919. doi: 10.1038/bjc.2011.164

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Copyright © 2011 Cancer Research UK

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Kaplan–Meier survival curve for relapse-free survival of early-stage breast cancer patients (n=82) who were CTC negative (n=66) or positive (n=16) at diagnosis. CTC-positive patients had a significantly poorer relapse-free survival than CTC-negative patients (univariate hazard ratio=4.72; 95% CI: 1.52–14.66; log rank test P=0.003). The number of patients at risk at each time point (months) are indicated for the CTC-negative (black) and CTC-positive (grey) groups. Abbreviations: CTC-positive or CTC-negative=positive or negative circulating tumour cell status according to quadratic discriminant analysis (QDA) score; FU=follow-up.