Table 1. Distribution of clinicopathological features, including Wnt5a methylation in primary colorectal carcinomas from Ontario and Newfoundland.
|
No. of cases (%)
|
||
|---|---|---|
| Ontario | Newfoundland | |
| Cases of primary colorectal carcinoma | 545 | 687 |
| Mean age (s.d.) | 60.7 (8.8) | 61.3 (9.4) |
| White ethnicity | 545 (100) | 687 (100) |
| Age | ||
| <50 | 61 (11.2) | 83 (12.1) |
| 50+ | 484 (88.8) | 604 (87.9) |
| Sex | ||
| Female | 261 (47.9) | 264 (38.4) |
| Male | 284 (52.1) | 423 (61.6) |
| Tumour location a | ||
| Proximal | 208 (38.2) | 287 (41.8) |
| Distal | 329 (60.4) | 390 (56.8) |
| Unavailable | 8 (1.5) | 10 (1.5) |
| TNM stage | ||
| 1 | 95 (17.4) | 101 (14.7) |
| 2 | 211 (38.7) | 235 (34.2) |
| 3 | 165 (30.3) | 206 (30.0) |
| 4 | 30 (5.5) | 144 (21.0) |
| Unavailable | 44 (8.1) | 1 (0.1) |
| Histological grade | ||
| Low | 43 (7.9) | 99 (14.4) |
| Moderate | 390 (71.6) | 504 (73.4) |
| High | 63 (11.6) | 71 (10.3) |
| Unavailable | 49 (9.0) | 13 (1.9) |
| Histological type b | ||
| Non-mucinous | 444 (81.5) | 601 (87.5) |
| Mucinous | 62 (11.4) | 86 (12.5) |
| Unavailable | 39 (7.2) | 0 (0.0) |
| MSI status | ||
| Stable | 385 (70.6) | 585 (85.2) |
| Low | 68 (12.5) | 27 (3.9) |
| High | 87 (16.0) | 68 (9.9) |
| Unavailable | 5 (0.9) | 7 (1.0) |
| MMR germline mutation | ||
| No | 178 (32.7) | 670 (97.5) |
| Yes | 15 (2.8) | 17 (2.5) |
| Unavailable | 352 (64.6) | |
| MMR protein status | ||
| Intact | 444 (81.5) | 605 (88.1) |
| Deficient | 76 (13.9) | 61 (8.9) |
| Unavailable | 25 (4.6) | 21 (3.1) |
| MLH1 methylation | ||
| No | 492 (90.3) | 410 (59.7) |
| Yes | 52 (9.5) | 19 (2.8) |
| Untested | 1 (0.2) | 258 (37.6) |
| BRAF V600E mutation | ||
| No | 463 (85.0) | 568 (82.7) |
| Yes | 63 (11.6) | 77 (11.2) |
| Unavailable | 19 (2.2) | 42 (6.1) |
| Wnt5a methylation | ||
| Unmethylated | 438 (80.4) | 562 (81.8) |
| Methylated | 107 (19.6) | 125 (18.2) |
Abbreviations: BRAF=v-raf murine sarcoma viral oncogene homolog B1; MLH1=mutL homolog 1; MMR=mismatch repair; MSI=microsatellite instability; TNM=tumour node metastasis.
a
Proximal tumour location includes lesions up to and including the splenic flexure.
b
Mucinous histology includes the presence of any mucin within the tumour stroma.