Table 3. Multivariate MSI analysis adjusted for age, sex, tumour location, and Wnt5a methylation status.
|
Ontario
|
Newfoundland
|
|||||
|---|---|---|---|---|---|---|
| Variable | Univariate P | Multivariate P | Multivariate OR (95% CI) | Univariate P | Multivariate P | Multivariate OR (95% CI) |
| Age | 0.95 | 0.16 | 0.98 (0.95, 1.01) | 0.06 | 0.002 | 0.96 (0.94, 0.99) |
| Female Sex | 0.003 | 0.27 | 1.36 (0.79, 2.35) | 0.05 | 0.31 | 1.33 (0.77, 2.29) |
| Proximal Location | 4.37 × 10−15 | 7.82 × 10−12 | 8.41 (4.57, 15.47) | 1.31 × 10−12 | 7.74 × 10−8 | 6.21 (3.19, 12.09) |
| Wnt5a Meth | 7.56 × 10−15 | 6.94 × 10−7 | 4.22 (2.39, 7.45) | 7.24 × 10−9 | 3.94 × 10−6 | 3.78 (2.15, 6.64) |
Abbreviations: CI=confidence interval; MSI=microsatellite instability; OR=odds ratio.