Table 2. Pathologic variables in patients undergoing preoperative chemotherapy±radiation therapy for gastric and gastrooesophageal junction adenocarcinoma, followed by R0 resection.
Number (%)
|
|||
---|---|---|---|
Variable | Non-pCR patients (n=549) | pCR patients (n=60) | P-value |
pT stage a | |||
T0b | 11 (2) | 60 (100) | |
T1a | 21 (4) | 0 | |
T1b | 48 (9) | 0 | |
T2 | 125 (23) | 0 | N/A |
T3 | 243 (44) | 0 | |
T4a | 93 (17) | 0 | |
T4b | 8 (1) | 0 | |
pN stage a | |||
N0 | 241 (44) | 60 (100) | |
N1 | 131 (24) | 0 | |
N2 | 97 (18) | 0 | N/A |
N3a | 59 (11) | 0 | |
N3b | 21 (4) | 0 | |
Extent of surgical lymphadenectomy | |||
D1 | 20 (4) | 1 (2) | |
D2 | 513 (93) | 57 (95) | 0.72c |
D3 | 16 (3) | 2 (3) | |
Number of positive LN (for ⩾N1; mean, IQR) | 3.0 (1–8) | 0 (0) | N/A |
Number of LN examined (mean, IQR) | 23 (15–29) | 29 (25–32) | 0.04d |
Pathologic treatment effect (mean %, IQR) | 45 (10–95) | 100 | N/A |
Abbreviations: IQR=interquartile range; LN=lymph node; N/A=not applicable (no statistical analysis performed, as differences are defined by subgroup stratification); pCR=pathologic complete response.
AJCC 7th edn, 2010.
T0N1 (n=9) and T0N2 (n=2) – 1 patient has recurred after a median follow-up of 17 months.
χ2 text.
Wilcoxon rank sum test with continuity correction. Bold values indicate significant differences.