Table 3. Timing and patterns of recurrence in patients undergoing preoperative chemotherapy±radiation therapy for gastric and gastrooesophageal junction adenocarcinoma, followed by R0 resection.
|
Number (%)
|
|||
|---|---|---|---|
| Variable | Non-pCR patients (n=549) | pCR patients (n=60) | P-value |
| Recurrence | |||
| Yes | 242 (44) | 14 (23) | — |
| Probability of recurrence | |||
| 1 year | 28% | 12% | |
| 3 years | 46% | 27% | 0.01a |
| 5 years | 51% | 27% | |
| First recurrence location b | |||
| Local/regional | 95 (43) | 6 (43) | 1.00c |
| Distant | 128 (57) | 8 (57) | |
| CNS as site of first recurrence | 10 (4) | 5 (36) | 0.01c |
Abbreviations: CNS=central nervous system; pCR=pathologic complete response.
a
Log-rank test.
b
Recurrence location information available in 223 out of 242 patients (92%) that recurred in the non-pCR patient group.
c
χ2 test. Bold values indicate significant differences.