Table 2. Treatment toxicity.

	CDI arm (N=74)			CTI arm (N=74)
	All grades	Grade 3	Grade 4	All grades	Grade 3	Grade 4
Fatigue	45 (61%)	11 (15%)	1 (1%)	43 (58%)	11 (15%)	2 (3%)
Fever	38 (51%)	5 (7%)	—	40 (54%)	7 (9%)	—
Nausea/vomiting	47 (63%)	11 (15%)	—	44 (59%)	7 (9%)	—
Constipation	8 (11%)	—	—	9 (12%)	—	—
Diarrhoea	5 (7%)	—	—	5 (7%)	—	—
Anorexia	15 (20%)	6 (8%)	—	17 (23%)	3 (4%)	1 (1%)
Leukocytes	14 (19%)	1 (1%)	1 (1%)	21 (28%)	3 (4%)	2 (3%)
Neutropenia	28 (38%)	7 (9%)	4 (5%)	29 (39%)	10 (14%)	7 (9%)
Thrombocytopenia	23 (31%)	3 (4%)	2 (3%)	22 (30%)	3 (4%)	4 (5%)
Anaemia	23 (31%)	3 (4%)	—	35 (47%)	6 (8%)	1 (1%)
Lymphopenia	7 (9%)	2 (3%)	—	10 (14%)	1 (1%)	2 (3%)
Liver function	23 (31%)	3 (4%)	—	18 (24%)	3 (4%)	2 (3%)

Abbreviations: CDI=DTIC-based chemotherapy; CTI=TMZ-based chemotherapy; DTIC=Dacarbazine; TMZ=Temozolomide.

Data are N (%).