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. 2011 May 24;104(12):1869–1876. doi: 10.1038/bjc.2011.180

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Copyright © 2011 Cancer Research UK

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Incorporation of S⁴TdR into cellular DNA. Cell lines were incubated in concentrations of S⁴TdR as indicated on the x axis for two cell-doubling times. Following DNA extraction and digestion, nucleosides were analysed using LC/MS/MS to determine the percentage of DNA thymidine replaced by S⁴TdR (y axis).