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Relationship between methadone enantiomers clearance and CYP3A activity. (A) IV methadone clearance and hepatic CYP 3A activity (IV alfentanil clearance) (B) apparent oral methadone clearance and first-pass CYP 3A activity (oral alfentanil apparent clearance). Each data point is the result for a single subject. There were no significant correlations between methadone clearance and CYP3A activity.
