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. Author manuscript; available in PMC: 2011 Jun 9.
Published in final edited form as: Anesthesiology. 2009 Mar;110(3):660–672. doi: 10.1097/ALN.0b013e3181986a9a

Table 3.

Fexofenadine Pharmacokinetic Parameters

Control Acute Ritonavir/Indinavir Steady-state Ritonavir/Indinavir
Cmax, ng/ml 164 ± 125 404 ± 191* 464 ± 228*
AUC0-∞, ng · h−1 · ml−1 859 ± 438 4160 ± 1510* 3540 ± 1530*
AUC0-∞ ratio, ritonavir-indinavir/control 5.0 (3.5–7..3) 4.2 (2.9–5.9)
CL/F, ml · kg−1 · min−1 20.8 ± 8.3 4.2 ± 2.0* 5.3 ± 3.3*
Elimination t1/2, h 12.4 ± 2.2 8.3 ± 3.2* 7.5 ± 0.7*
*

Significantly different from control (P < 0.05). AUC, area under the plasma concentration-time curve; Cmax, peak plasma concentration; CL/F, apparent oral clearance of fexofenadine.

Results are the arithmetic mean ± SD (n=12), except the area under the concentration-time curve (AUC) ratio (ritonavir/control), which is the geometric mean (90% confidence interval).