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. 2011 Feb;2(2):140–150. doi: 10.1177/1947601911408888

Figure 6.

Figure 6.

Impaired miRNA processing–enhanced in vitro invasion requires upregulated uPA expression. (A) Cells were transduced with control lentiviral vector or vector containing Drosha, DGCR8, or Dicer shRNA for 4 days. The population of the transduced cells was detached and analyzed for their ability to invade Matrigel. The invading cells on the undersurface of invasion chambers were stained and counted under a phase-contrast microscope. Data are mean ± SE (n = 3). *P < 0.005 versus control. (B) Scrambled RNA or uPA siRNA pool (5 µM) was transfected into control, Drosha, DGCR8, or Dicer knockdown cells for 3 days and then analyzed for in vitro invasion. Data are mean ± SE (n = 3). #P < 0.05 versus scrambled RNA. *P < 0.005 versus scrambled RNA.