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Membrane leakage induced by amyloidogenic human IAPP. Liposomes were prepared with encapsulated 70-kDa fluorescein dextran. Leakage profiles are observed by addition of the fluorescence quencher DPX at the indicated time points (τDPX) after addition of 4 μM human IAPP. Amyloid formation (black) as measured in a matched dextran-free sample differing only by the addition of the amyloid indicator fluorophore, ThT.
