Fig. 1.

(A) Schematic diagram of the chain of springs and binding sites used in the model. The binding sites on the springs and the two layers of sites are represented by small and big open circles, respectively. The enzyme particles are shown as filled black circles. The particle at the bottom layer can move up, left, or right whereas the particle at the top can move down, left, or right. The particle on the spring can move only up or down. (B) The binding probability p_on defined by Eq. 1 and the diffusion probability p_d are a function of the number of visits n at a fixed site. Lines of different styles correspond to Δp = 0.10 (solid lines), Δp = 0.16 (dotted lines), Δp = 0.20 (dashed lines), and Δp = 0.24 (dash-dotted lines). The lines above and below the horizontal dashed line at p = 0.333 correspond to p_d and p_on, respectively. The vertical dashed line represents the region where the isotropic behavior with p = 0.333 is reached.