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. 2011 May 23;108(23):9572–9577. doi: 10.1073/pnas.1106291108

Fig. 3.

Fig. 3.

PINK1−/− mice develop age-dependent cardiac hypertrophy and LV dysfunction. (A) Heart/body-weight ratio (Left) and Masson stain (Right) of myocardial longitudinal sections. (Scale bar, 2 mm.) Mean ± SEM. *P < 0.05. Sample size is indicated inside respective bar. (B) Fractional shortening (FS) determined by echocardiography. Mean ± SEM. *P < 0.05. **P < 0.05 versus PINK1−/− 2 mo. (C) Cardiomyocyte size (Left) and representative immunofluorescence micrographs of wheat germ agglutinin–Alexa Fluor 488 conjugate (WGA) stained myocardial cross-sections (Right). Mean ± SEM. #P < 0.05. *P < 0.05 versus PINK1+/+ 2 mo. (D) Quantitative RT-PCR analysis of mRNA levels of hypertrophic marker genes normalized to GAPDH mRNA. The ratio of hypertrophic markers to GAPDH in PINK1+/+ hearts at 2 mo was arbitrarily set to 1. *P < 0.05 versus PINK1+/+ 2 mo. Mean ± SEM. #P < 0.05 versus PINK1+/+ 6 mo.