Table 2.
Demographic and metabolic parameters of study population according to FEN1 -10154G>T, FADS2 rs174575, FADS2 rs2727270 and FADS3 rs1000778C>T
| FEN1 -10154G>T | FADS2 rs174575 | FADS2 rs2727270 | FEN1 -10154G>T | |||||
|---|---|---|---|---|---|---|---|---|
| GG (n = 259) | GT+TT (n = 308) | CC (n = 471) | CG+GG (n = 96) | CC (n = 323) | CT+TT (n = 244) | GG (n = 259) | GT+TT (n = 308) | |
| Age (year) | 48.6 ± 9.8 | 48.7 ± 9.0 | 48.9 ± 9.4 | 47.7 ± 9.0 | 48.4 ± 9.6 | 49.0 ± 9.0 | 49.1 ± 9.6 | 48.3 ± 9.1 |
| BMI (kg/m2) | 24.4 ± 2.9 | 24.4 ± 2.5 | 24.3 ± 2.7 | 24.8 ± 2.6 | 24.4 ± 2.8 | 24.4 ± 2.5 | 24.3 ± 2.6 | 24.5 ± 2.8 |
| Waist (cm) | 85.1 ± 6.9 | 85.9 ± 7.5 | 85.3 ± 7.3 | 86.8 ± 7.2 | 85.1 ± 7.0 | 86.0 ± 7.5 | 85.4 ± 7.3 | 85.6 ± 7.3 |
| Current smokers (%) | 34.7 | 39.0 | 38.0 | 32.3 | 35.3 | 39.3 | 35.7 | 38.3 |
| Current drinkers (%) | 83.4 | 84.4 | 83.4 | 86.5 | 84.8 | 82.8 | 79.6 | 88.2 |
| Sysptolic BP (mmHg) | 123.0 ± 14.7 | 123.2 ± 14.0 | 122.9 ± 14.3 | 124.0 ± 14.3 | 123.1 ± 14.7 | 123.2 ± 13.8 | 123.1 ± 13.7 | 123.1 ± 14.8 |
| Diastolic BP (mmHg) | 76.4 ± 11.1 | 77.3 ± 10.9 | 76.8 ± 10.9 | 77.4 ± 11.6 | 76.3 ± 11.1 | 77.6 ± 10.9 | 76.9 ± 10.5 | 76.9 ± 11.4 |
| TG (mg/dL)§ | 137.9 ± 76.2 | 132.1 ± 71.6 | 133.1 ± 73.7 | 143.1 ± 73.8 | 136.7 ± 75.2 | 132.2 ± 71.9 | 135.5 ± 80.7 | 134.1 ± 66.5 |
| Total-C (mg/dL)§ | 194.5 ± 32.5 | 190.3 ± 33.8 | 192.4 ± 33.3 | 191.4 ± 33.2 | 194.4 ± 33.4 | 189.3 ± 33.0 | 192.5 ± 32.3 | 192.0 ± 34.2 |
| HDL-C (mg/dL)§ | 50.0 ± 12.3 | 50.7 ± 13.7 | 50.4 ± 13.3 | 50.2 ± 12.1 | 50.5 ± 12.3 | 50.3 ± 14.0 | 49.6 ± 12.9 | 51.1 ± 13.2 |
| LDL-C (mg/dL) | 117.2 ± 31.4 | 113.4 ± 31.6 | 115.6 ± 31.8 | 112.6 ± 30.3 | 116.8 ± 32.1 | 112.9 ± 30.8 | 116.2 ± 31.3 | 114.0 ± 31.8 |
| non-HDL-C (mg/dL) | 144.5 ± 33.1 | 139.6 ± 34.5 | 142.0 ± 34.2 | 141.2 ± 32.6 | 143.9 ± 33.8 | 139.1 ± 34.0 | 142.8 ± 33.7 | 140.8 ± 34.2 |
| ApoA1 (mg/dL) | 139.9 ± 23.0 | 141.0 ± 26.1 | 140.4 ± 24.0 | 140.9 ± 28.6 | 141.9 ± 24.5 | 138.9 ± 24.8 | 140.8 ± 26.7 | 140.2 ± 22.7 |
| ApoB (mg/dL)§ | 88.6 ± 22.3 | 85.9 ± 24.6 | 87.0 ± 24.0 | 87.8 ± 21.3 | 88.6 ± 22.9 | 85.4 ± 24.3 | 85.4 ± 22.9 | 88.7 ± 24.1 |
| Glucose (mg/dL) | 93.3 ± 11.1 | 92.5 ± 10.4 | 92.7 ± 10.9 | 93.9 ± 9.8 | 93.4 ± 10.7 | 92.2 ± 10.8 | 92.3 ± 10.6 | 93.4 ± 10.9 |
Means ± S.D. or %, §Tested by log-transformed, Performed by independent t-test or qui-square test, *P < 0.05, **P < 0.01 and ***P < 0.001 compared with major allele for each genotype.
BMI: body mass index, BP: blood pressure, TG: triglyceride, C: cholesterol, Apo: apolipoprotein, HOMA-IR(homeostatis model assessment-insulin resistance): {fasting insulin (μIU/ml) × fasting glucose (mmol/l)}/22.5.