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Alternative interaction network of MIPBs and MIPEs. MIPBs and MIPEs have unusual substitutions in helix 3 and loop B suggesting an alternative network of interactions in the packing core next to the pore at the cytoplasmic side. SoPIP2;1 is shown in green and a model of OlMIPB1;1 is superimposed in brown. The side chains at the substituted positions are drawn as sticks and their potential interactions are indicated by dashed lines with distances in Å.
