Table 2.
The associations between Ku70 polymorphisms and gastric cancer risk
| Case (%) | Control (%) | Adjusted ORa (95% CI) | P-value | |
|---|---|---|---|---|
| promoter T-991C (rs5751129) | ||||
| TT | 106 (77.9) | 502 (89.6) | 1.00 (ref) | |
| TC | 26 (19.1) | 52 (9.3) | 2.41 (1.53-3.88) | 0.0020 |
| CC | 4 (3.0) | 6 (1.1) | 3.21 (0.96-9.41) | 0.0837 |
| P for trend | 2.87 (1.37-5.02) | <0.0001 | ||
| (TC+CC) vs TT | 2.48 (1.74-3.92) | 0.0005 | ||
| CC vs (TT+TC) | 2.67 (0.71-9.69) | 0.1114 | ||
| Promoter G-57C (rs2267437) | ||||
| CC | 95 (69.9) | 383 (68.4) | 1.00 (ref) | |
| CG | 37 (27.2) | 167 (29.8) | 0.91 (0.48-1.38) | 0.6722 |
| GG | 4 (2.9) | 10 (1.8) | 1.56 (0.55-4.97) | 0.4954 |
| P for trend | 0.93 (0.53-3.34) | 0.6164 | ||
| (CG+GG) vs CC | 0.98 (0.63-1.52) | 0.8367 | ||
| GG vs (CC+CG) | 1.52 (0.58-5.01) | 0.4917 | ||
| promoter A-31G (rs132770) | ||||
| GG | 109 (80.1) | 459 (82.0) | 1.00 (ref) | |
| GA | 19 (14.0) | 73 (13.0) | 1.16 (0.71-1.93) | 0.7763 |
| AA | 8 (5.9) | 28 (5.0) | 1.25 (0.51-2.68) | 0.6642 |
| P for trend | 1.18 (0.68-2.34) | 0.9065 | ||
| (GA+AA) vs GG | 1.14 (0.73-1.76) | 0.6227 | ||
| AA vs (GG+GA) | 1.03 (0.37-3.01) | 0.6673 | ||
| intron 3 (rs132774) | ||||
| GG | 113 (83.1) | 459 (82.0) | 1.00 (ref) | |
| GC | 23 (16.9) | 101 (18.0) | 0.91 (0.60-1.73) | 0.8040 |
| CC | 0 (0.0) | 0 (0.0) |
a Adjusted by age and gender; the line with ORs that significantly differ from 1.00 are bolded