Table 4. Genes affected by both cadmium and thapsigargin exposures.
| Gene | Name | Descriptiona |
| DDIT3 | DNA damage-inducible transcript 3 | Transcription factor that promotes cell death during ER stress |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | Responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis |
| HSPA5 | Heat shock 70kDa protein 5 | Involved in the folding and assembly of proteins in the ER during stress |
| TNF | Tumor necrosis factor | Multifunctional proinflammatory cytokine that is mainly secreted by macrophages |
| INHBA | Inhibin beta A subunit | Member of the transforming growth factor-beta superfamily that may acts as both a growth/differentiation factor and a hormone |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | Part of the transcription factor complex AP-1 and regulates cell proliferation, differentiation, and transformation |
| PPP1R15A | Protein phosphatase 1, regulatory (inhibitor) subunit 15A | Helps mediate apoptosis following stressful conditions |
| GEM | GTP binding protein over-expressed in skeletal musclehttp://www.genenames.org/data/hgnc_data.php?hgnc_id=4234 | Belongs to the RAD/GEM family of GTP-binding proteins, could play a role in receptor-mediated signal transduction |
| EGR1 | Early growth response 1http://www.genenames.org/data/hgnc_data.php?hgnc_id=3238 | Transcriptional regulator of genes required for differentiation and mitogenesis |
| ATF3 | Activating transcription factor 3 | Member of the CREB protein family and mediates pro-apoptotic effects of p38 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | Part of the transcription factor complex AP-1 and regulates cell proliferation, differentiation, and transformation |
a
Name and description were determined using GeneCards [59].