Figure 2. Age-dependent changes in basal blood glucose and body weight.
A, Blood glucose in 2-, 4- and 6-mo-old wild-type (WT) and IDE-KO (KO) mice following overnight fasting. Note that 2-mo-old IDE-KO mice exhibit significantly lower basal glucose levels relative to controls. B, Body weight of fasted 2-, 4- and 6-mo-old WT and IDE-KO mice. Note that IDE-KO mice weigh significantly less than wild-type controls mice at 2 months yet significantly more at 6 months of age. Data are mean ± SEM of 10–12 mice per group. *P<0.05 IDE-KO vs. WT as determined by 2-tailed Student's t test.