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. 2011 Jun 9;6(6):e20818. doi: 10.1371/journal.pone.0020818

Figure 3. Age-dependent emergence of the diabetic phenotype in IDE-KO mice.

Figure 3

A–C, Glucose tolerance tests in 2- (A), 4-(B), and 6-mo-old (C) wild-type (WT) and IDE-KO (KO) mice. Note that 2-mo-old IDE-KO mice exhibit improved glucose tolerance at some time points. Data are mean ± s.d. of 10–12 mice per condition. *P<0.05. D–F, Insulin tolerance tests in 2- (D), 4-(E), and 6-mo-old (F) WT (WT) and IDE-KO (KO) mice. Note the trend towards improved insulin tolerance in 2-mo-old IDE-KO mice. Data are mean ± s.d. of 10–12 mice per condition. *P<0.05 IDE-KO vs. WT as determined by 2-tailed Student's t test.