FIGURE 6.

CCR5 is dispensable for Treg migration once in the periphery. RAG1^−/− mice were reconstituted with WT CD4⁺ T cells and WT or CCR5^−/− CD4⁺ CD25⁺ cells purified from the spleen and infected with 2 × 10⁶ yeasts 1 d later. Number of CD4⁺ CD25⁺ Foxp3⁺ cells (A) and fungal burden (B) in the lungs of RAG1^−/− mice reconstituted with WT or CCR5^−/− CD4⁺CD25⁺ cells at day 14 postinfection. Fungal burden is presented as the mean number of CFUs. Data represent the mean ± SEM (n = 8–12) from two to three experiments. **p < 0.01.