Table I.
Proliferation of thymic populations
| Phenotype | % Proliferating (BrdU+)
|
|
|---|---|---|
| WT | CCR5−/− | |
| DN (CD4−CD8−) | 32.0 ± 1.0 | 34.2 ± 0.9 |
| DP (CD4+CD8+) | 31.7 ± 3.0 | 37.1 ± 2.5a |
| CD4+ SP (CD4+CD8−) | 5.9 ± 0.2 | 6.6 ± 0.3 |
| CD8+ SP (CD4−CD8+) | 31.2 ± 1.1 | 37.4 ± 1.8a |
| CD4+CD25+ | 8.3 ± 1.2 | 7.7 ± 1.2 |
| CD4+Foxp3+ | 29.6 ± 2.4 | 42.3 ± 3.1a |
Data represent the mean ± SEM of two to three experiments (n = 6–12). Proliferation was measured by BrdU incorporation and expressed as percent of total thymic population.
a
p < 0.05 versus WT.