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. 2011 Jun 9;6(6):e21000. doi: 10.1371/journal.pone.0021000

Figure 6. The plasma concentration versus time curve (AUC) of 5-FU post irradiation was reversed by the matrix metalloproteinase-8 (MMP-8) inhibitor.

Figure 6

The area under the plasma concentration versus time curve (AUC) of 5-FU 100 mg/kg administered to rats in the control group without solvent, control group with solvent, whole pelvic 2-Gy irradiation with solvent, and whole pelvic 2-Gy irradiation with solvent and MMP-8 inhibitor. The transverse axis illustrates time in minutes and the vertical axis represents the concentration of 5-FU in the plasma. Each group's data was collected from four rats.