Table 1. Plasma pharmacokinetics of 5-fluorouracil (100 mg/kg, i.v.) in rats after whole pelvic irradiation with or without 0.5 Gy or 2 Gy.
| Parameters | Controls | Whole pelvic irradiation | |
| 0 Gy | 0.5 Gy | 2 Gy | |
| AUC (min µg/mL) | 4725±402 | 3893±329* | 3711±484* |
| t1/2 (min) | 34.7±9.6 | 24.7±3.5 | 29.9±7.1 |
| Cmax (µg/mL) | 164±36 | 167±23 | 179±19 |
| MRT (min) | 36.5±3.0 | 30.9±3.7* | 25.0±4.8* |
| CL (mL/kg/min) | 21.3±1.9 | 25.8±2.0* | 27.3±3.6* |
| Vss (mL/kg) | 778±88 | 775±116 | 670±60 |
AUC: area under the plasma concentration vs. time curve; t1/2: terminal elimination phase half-life; Cmax: maximum observed plasma concentration; MRT: mean residence time; CL: total plasma clearance; Vss: volume of distribution at steady state.
*The mean difference is significant at the 0.05 level in comparison to the control group.