Table 2. The bile of 5-Fluorouracil (100 mg/kg, i.v.) pharmacokinetics in rats after whole pelvic irradiation with and without 0.5 and 2 Gy.

Parameters	Controls	Whole pelvic irradiation
	0 Gy	0.5 Gy	2 Gy
AUC (min µg/mL)	1180±49	1477±78*	1540±101*
t1/2 (min)	9.2±0.4	10.3±0.5	12.9±2.8
Cmax (µg/mL)	129±22	120±14	93±6.0* †
MRT (min)	8.9±1.1	11.1±0.5*	13.9±1.3* †
CL (mL/kg/min)	84.8±3.6	67.9±3.6*	65.1±4.3*
Vss (mL/kg)	754±102	753±25	903±55*

AUC: area under the plasma concentration vs. time curve; t_1/2: terminal elimination phase half-life; Cmax: maximum observed plasma concentration; MRT: mean residence time; CL: total plasma clearance; Vss: volume of distribution at steady state.

*The mean difference is significant at the 0.05 level in comparison to the control group.

^†The mean difference is significant at the 0.05 level between the 0.5 and 2 Gy groups.