Figure 6. Specific SKN-1–mediated responses to impaired protein synthesis and degradation.

SKN-1 target genes are activated through distinct mechanisms by interference with translation initiation or elongation, so that TEF RNAi (red) induces a more restricted set of SKN-1 target genes than TIF RNAi (blue). TEF RNAi also impairs UPS activity, supporting the idea that proteasome activity and translation elongation are mechanistically coupled processes. In the intestine, SKN-1 is also important for the “bounce-back” response to proteasome inhibition, and for UPS activity under normal conditions (green).