Table 5. The clinical features of affected patients with a ZNF644 gene mutation in the 300 sporadic cases with high myopia.

Family	Subject No.	Age (Yr)*	Gender	Axial length (mm)**		Refractive errors (DS)**		Fundus appearance**		ZNF644 mutation
				OD	OS	OD	OS	OD	OS	Nucleotide change	Exon	Amino acid change	Chr.1 location
JS007	JS007001	26	M	26.1	26.1	−10.02	−9.47	conus	conus	2091 A>G	3	I587V	91177740
JS103	JS103001	55	F	29.1	29.2	−14.47	−15.03	tigroid, CA, Fuchs spot	tigroid, CA, Fuchs spot	2091 A>G	3	I587V	91177740
JS104	JS104001	53	M	31.5	29.4	−17.25	−16.49	tigroid, CA	tigroid, CA, Fuchs spot	2091 A>G	3	I587V	91177740
JS078	JS078001	28	F	27.8	27.0	−12.03	−9.47	tigroid, macular atrophy	tigroid or tesselated	2091 A>G	3	I587V	91177740
JS131	JS131001	31	M	27.2	27.1	−14.67	−15.04	tigroid or tesselated	tigroid	2091 A>G	3	I587V	91177740
JS010	JS010001	29	M	26.5	26.1	−10.52	−9.54	conus	conus	2180 C>G	3	R680G	91177461
JS064	JS064001	32	F	28.4	28.4	−9.54	−10.97	tigroid, conus	tigroid	2238 G>A	3	C699Y	91177403
JS080	JS080001	25	F	26.8	27.0	−11.26	−11.45	tigroid	tigroid	2238 G>A	3	C699Y	91177403
JS075	JS075001	19	M	30.5	28.5	−18.02	−15.02	tigroid, conus	tigroid	4138 C>G	6	3′UTR+12 C>G	91154931
JS027	JS027001	63	F	26.3	26.5	−8.02	−9.04	tigroid, conus	tigroid, conus	4718 G>A	6	3′UTR+592 G>A	91154351
JS047	JS047001	46	M	28.5	28.7	−15.96	−16.02	tesselated, conus, CNV	tesselated, conus	4718 G>A	6	3′UTR+592 G>A	91154351

*The age when the patients were recruited.

**OD: right eye; OS: left eye; DS, diopter sphere; CA: choriocapillaris atrophy; CNV: choroidal neovascularization.