Table 1.
Top Accuracy Genes Selected by LDA and Class Prediction Method for Classifying BRCA1 Mutation Positive Tissue Samples
| Colon | Description | Accuracy |
|---|---|---|
| LDA | ||
| 212198 | tumor protein p53-binding protein, 2 | 0.954545 |
| 897646 | splicing factor, arginine/serine-rich 4 | 0.954545 |
| 344352 | ESTs | 0.954545 |
| 42888 | interleukin enhancer binding factor 2, 45kD | 0.954545 |
| 366647 | butyrate response factor 1 (EGF-response factor 1) | 0.954545 |
| 242037 | Human putative cyclic G1 interacting protein mRNA, partial sequence | 0.909091 |
| 248531 | guanine-monophosphate synthetase | 0.909091 |
| 46182 | CTP synthase | 0.909091 |
| 840702 | selenophosphate synthase; Human selenium donor protein | 0.909091 |
| 811930 | KIAA0020 gene product | 0.909091 |
| 687397 | Ras suppressor protein 1 | 0.909091 |
| 566887 | chromobox homolog 3 (Drosophila HP1 gamma) | 0.909091 |
| 81331 | fatty acid binding protein 5 (psoriasis-associated) | 0.909091 |
| 202034 | ESTs, highly similar to 45kDa splicing factor [Heme sapiens] | 0.909091 |
| 307843 | ESTs | 0.909091 |
| 247818 | ESTs | 0.909091 |
| 46019 | minichromosome maintenance deficient (S. cerevisiae) 7 | 0.909091 |
| 32790 | mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1) | 0.909091 |
| Class Prediction Method (Hedenfalk et al. 2001) | ||
| 212198 | tumor protein p53-binding protein, 2 | 0.954545 |
| 366647 | butyrate response factor 1 (EGF-response factor 1) | 0.954545 |
| 840702 | selenophosphate synthetase; Human selenium donor protein | 0.909091 |
| 566887 | chromobox homolog 3 (Drosophila HP1 gamma) | 0.909091 |
| 307843 | ESTs | 0.909091 |
| 247818 | ESTs | 0.909091 |
| 46019 | minichromosome maintenance deficient (S. cerevisiae) 7 | 0.909091 |
| 26082 | very low density lipoprotein receptor | 0.863636 |
| 897781 | keratin 8 | 0.818182 |